The impact of Global Climate Change on Water Quantity and Quality: A System Dynamics Approach to the US-Mexican Transborder Region

The potential impacts of Global Climate Change (GCC) in zones where water is scarce, such as along the US–Mexico border is, and will continue to be, a key concern for the future sustainability of humanity. This paper estimates the variation in quality/quantity water due to climate change and assesses its impact on community development in the US–Mexico border region of the Rio Grande/Rio Bravo Water Basin. To estimate variation in different water quality parameters, we use a conservative model with most probable scenarios for temperature/precipitation produced by the International Panel on Climate Change. We propose a system dynamics model to understand the complex interaction of factors governing the quantity/quality of water and their effects on social and economic conditions. The model simulates, for a 70-year period, policies and decisions that have the potential to improve conditions and prevent risks that may lead to social unrest and hinder economic development

Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

Supplemental material available at www.aaojournal.org. Supported by AbbVie, Inc., and the Fundamentals of Care for Uveitis Initiative National Faculty. This manuscript was developed subsequent to an AbbVie-sponsored literature review of noninfectious, nonanterior uveitis. The meeting was conducted to understand the available literature regarding the management of patients with noninfectious, nonanterior uveitis. The program involved a total of 139 experts from 28 countries, who were selected for participation by AbbVie. However, AbbVie was not involved in the development of the manuscript. The authors maintained complete control over the content and this manuscript reflects the opinions of the authors. AbbVie selected the discussion participants and reviewed the final manuscript draft for scientific accuracy, but the authors determined the final content. All authors made substantial contributions to the article or critically revised it for important intellectual content and approved the final manuscript. AbbVie provided funding to invited participants, including honoraria for their attendance at the meetings. Travel to and from the meetings was reimbursed. No payments were made to the authors for the development of this manuscript. Dhinakaran Sambandan, PhD, and Shula Sarner, PhD, of Lucid Partners, Burleighfield House, Buckinghamshire, United Kingdom, provided medical writing and editorial support to the authors in the development of this manuscript; financial support for these services was provided by AbbVie. AbbVie reviewed the manuscript, but was not involved in the methodology, data collection and analysis, or completion of this manuscript.Peer reviewedPublisher PD

A population-based study of reduced sleep duration and hypertension : the strongest association may be in premenopausal women

Objectives: Recent evidence indicates that reduced sleep duration may be associated with an increased risk of hypertension with possibly stronger effects among women than men. We therefore examined cross-sectional sex-specific associations of sleep duration with hypertension in a large population-based sample from the Western New York Health Study (1996<2001). Methods: Participants were 3027 white men (43.5%) and women (56.5%) without prevalent cardiovascular disease (median age 56 years). Hypertension was defined as blood pressure at least 140 or at least 90&mmHg or regular use of antihypertensive medication. Multivariate logistic regression analyses were performed to estimate odds ratios (ORs) of hypertension comparing less than 6&h of sleep per night versus the reference category (&6&h) while accounting for a number of potential confounders. Results: In multivariate analyses, less than 6&h of sleep was associated with a significant increased risk of hypertension compared to sleeping at least 6&h per night, only among women [OR&=&1.66 (1.09 to 2.53)]. No significant association was found among men [OR&=&0.93 (0.62 to 1.41)]. In subgroup analyses by menopausal status, the effect was stronger among premenopausal women [OR&=&3.25 (1.37 to 7.76)] than among postmenopausal women [OR&=&1.49 (0.92 to 2.41)]. Conclusion: Reduced sleep duration, by increasing the risk of hypertension, may produce detrimental cardiovascular effects among women. The association is independent of socioeconomic status, traditional cardiovascular risk factors, and psychiatric comorbidities, and is stronger among premenopausal women. Prospective and mechanistic evidence is necessary to support causality

Potential Therapeutic and Effective Properties of Soft Tissue Liners

Soft tissue liners are polymer materials between the oral tissue and the surface of the denture. They have an essential role in reducing the effect of the masticatory force on the oral mucosa. This short review gleaned data on soft tissue liners to highlight their potential therapeutic importance in the management of denture-related stomatitis and their comparison to other materials. Published articles in many databases were collected using keywords with soft liner properties, viscoelastic, dental materials, impression technique, and additive liner materials. The soft liners were compared to the viscoelastic oral mucosa, and their influences on the control of denture plaque were highlighted too. Their application in the treatment of denture-related stomatitis, as well as adhesion and biofilm formation, was highlighted. The result showed that soft tissue liners have high therapeutic efficacy and effective properties in treating denture stomatitis due to the incorporation of chlorhexidine, antifungal, and antimicrobial agents. The use of soft liners improved ridge resorption and had a crucial effect on the loss of denture fit and stability. In addition, soft tissue liners in combination with additive materials recovered the effect of saliva on the formation and adhesion of biofilm. Uniquely, the application of soft liners in the functional impression technique was ideal, due to their extensive physical properties, their viscoelasticity, and the immediate poured impression. Therefore, soft liners are highly recommended in many dental conditions such as dentures opposing natural dentition, resorption of irregular bone, immediate implant placement, tooth undercuts, oral mucosa atrophy, bruxism, and xerostomia

Fear, Knowledge, and Modification of Practice among Iraqi Dentists to Fight Novel Coronavirus Disease (COVID-19) Pandemic

Health care workers, especially doctors and nurses who are in direct contact with COVID-19 patients are on high-risk professions despite wearing full protective equipment. This study aimed to assess the fear and emotional stress among Iraqi dentists from getting infected with COVID-19 and also their knowledge in preventing this disease. A cross-sectional study using an online survey questionnaire consisted of 22 questions was implemented using Google Forms. The study started after gaining the agreement of the authority. The questionnaire was put out on social media; well known Iraqi dentist’s Facebook groups, and through e-mail. The study covered all the governorates of Iraq. The data were processed using SPSS. The sample was 516 dentists (216 males, and 255 females) and 218 participants were graduates, 249 postgraduates, and 49 of them were students. Results showed that, dentists who were afraid of getting infected with COVID-19 were 82%. Iraqi dentists have knowledge about the Novel COVID19 and are afraid of getting infected. Iraqi dentists need modifications in their practice to protect themselves and their patients from this pandemic

The criminalization of polyamory perspective Islamic penal law and Indonesian new penal code

Regardless of the social stigma faced, polyamory has become a widely discussed issue and has received much attention in various fields. This study aims to examine the legal aspects regarding the criminalization of polyamory from the perspective of Islamic criminal law and the new penal code in Indonesia. This study is a type of normative juridical research with a conceptual and statutory approach. The research results show that any sexual relation outside of legal marriage is considered adultery in Islam, requiring criminal sanctions for the perpetrators. Polyamory cases involving same-sex couples are also included in the criminal act. In the Indonesian legal context, although the term polyamory is not mentioned explicitly, the new Penal Code has the potential to criminalize polyamorous perpetrators with the latest regulations regarding adultery and cohabitation offenses. This new penal code can also criminalize homosexual behaviour including lesbian, gay, bisexual, transgender, and Queer plus(LGBTQ+) people. However, the perpetrator of polyamory can only be convicted if there is a complaint from the aggrieved party (i.e. the legal spouse, children, and parents of the perpetrator), because those articles fall into the category of absolute complaint offenses. Looking at the cultural values of Indonesian society, especially the teachings of Islam as a religion adhered to by the majority of citizens, the criminalization of polyamory should be included in the ordinary complaint offense so that it can be in line with the living norms in society

Norma. Portal jurídic de Barcelona : orígens i desenvolupament

Ponència de la Sra. Montserrat Cabré, tècnica del Servei de Documentació i Accés al Coneixement (SEDAC), a la Jornada CCUC 2021: projectes i serveis bibliotecaris cooperatius el 12-11-202

Alpha-particle-induced complex chromosome exchanges transmitted through extra-thymic lymphopoiesis in vitro show evidence of emerging genomic instability

Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk estimates for leukaemia remain uncertain. To further our understanding of α-particle effects in target cells for leukaemogenesis and also to seek general markers of individual exposure to α-particles, this study assessed the transmission of chromosomal damage initially-induced in human haemopoietic stem and progenitor cells after exposure to high-LET α-particles. Cells surviving exposure were differentiated into mature T-cells by extra-thymic T-cell differentiation in vitro. Multiplex fluorescence in situ hybridisation (M-FISH) analysis of naïve T-cell populations showed the occurrence of stable (clonal) complex chromosome aberrations consistent with those that are characteristically induced in spherical cells by the traversal of a single α-particle track. Additionally, complex chromosome exchanges were observed in the progeny of irradiated mature T-cell populations. In addition to this, newly arising de novo chromosome aberrations were detected in cells which possessed clonal markers of α-particle exposure and also in cells which did not show any evidence of previous exposure, suggesting ongoing genomic instability in these populations. Our findings support the usefulness and reliability of employing complex chromosome exchanges as indicators of past or ongoing exposure to high-LET radiation and demonstrate the potential applicability to evaluate health risks associated with α-particle exposure.This work was supported by the Department of Health, UK. Contract RRX95 (RMA NSDTG)